Discover, rate, and discuss biology papers.

The paper develops an energy-dependent integrate-and-fire model to explain how neurons adapt their biophysical parameters under metabolic stress to maintain an optimal energy-information trade-off.

This study investigates the role of Casd1 in sialic acid O-acetylation of intestinal mucus and its impact on tissue damage susceptibility in mice.

The paper shows cancer cells adapt along a proliferation-robustness axis in response to TME components, leading to pro-tumor phenotypes.

This study uses femtosecond laser ablation to measure collagen fiber recoil in tendons, showing that hyaluronic acid (HA) is critical for fiber sliding and mechanical properties.

The paper explores tradeoffs between resolution and field of view in scanless temporally focused holographic optogenetic systems, demonstrating improved spatial control using high NA objectives.

The paper introduces an optimized iU-ExM protocol for high-resolution imaging of T. cruzi cytoskeletal structures and subcellular architecture using conventional confocal microscopy.

This study shows that deleting Phd2 in Crb1/Crb2-deficient mice partially improves retinal function and structure but does not correct underlying defects.

OocystMeter automates oocyst counting and sizing in mosquito midguts, revealing clustered spatial patterns in malaria infections.

This study identifies FGF21 as a specific ethanol-induced hormone through proteomic profiling of acute alcohol intoxication in humans.

The paper investigates how cell geometry and nuclear Cyclin B-Cdk1 concentration influence cytoplasmic Cdk1 wave propagation and cortical dynamics in large embryos.

This paper develops a heart-on-a-chip model to distinguish structural, biochemical, and contractile changes in myocardial ischemia-reperfusion injury, linking them to distinct clinical phenotypes.

The paper develops a minimal marine bacterial community to study crossfeeding interactions and shows how different species exploit metabolic byproducts in a controlled setting.

This study identifies NHERF-1 as a regulator of CD2 localization and function in auditory hair cells, showing its role in maintaining hearing and preventing degeneration.

This study shows how induced goals shift attention during memory encoding and bias narrative recall in a naturalistic setting.

The paper maps metabolite corona composition on 25 chemically modified carbon nanotubes in human plasma, showing polymer wrapping and defects influence class-specific enrichment.

This study examines how substrate curvature affects osteoblast gene expression over time, showing shifts from immediate-early gene activation to ECM remodeling and signaling changes.

This study shows that VIE marking in guppies does not affect growth but increases parasite burden and transmission rates over time.

The paper identifies a conserved axonal transcriptome involved in PGE2-induced sensitisation and shows Tnfrsf12a regulates neuronal excitability in DRG neurons.

This study uses genetics-guided targeted mass spectrometry to detect protein isoforms associated with bone mineral density, confirming their expression in clinical samples.

This paper introduces a multimodal microscope that uses a cGAN to generate virtual fluorescence images from phase contrast data, enabling virtual histological staining of bulk tissues.