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This paper introduces a data-driven framework for spatial thinning parameterization in ecological modelling, showing that optimal thinning parameters vary with species range size and that uniform approaches can lead to information loss or reduced spatial clustering.

This study identifies three splicing regulation patterns mediated by UAP56 and URH49 and their association with mRNA export pathways.

This study shows how a viral tRNA-like structure recruits host ribosomes for poly(A)-independent translation by binding to ribosomal subunits and substituting for poly(A) tails.

This study examines how ocean warming affects the microbiome of the sponge Haliclona sp., finding significant shifts in rare microbiota composition and potential acclimation through microbial symbionts.

PrEditR is a tool for designing sgRNAs for CRISPR-based base editors, allowing users to target specific amino acids and annotate resulting mutations.

This paper develops a dCas9-based tool to measure DNA sequence proximity and orientation, finding that rotational alignment significantly affects dCas9 interactions.

This study uses scRNA-seq to analyze the immune response to CHIKV infection, finding increased monocytes and dendritic cells, and a strong interferon response driven by monocytes.

The paper identifies shared genomic signatures of Arctic adaptation across distantly related plant species by comparing genome assemblies and analyzing selection pressures and repetitive elements.

This paper introduces a maximum-likelihood framework to estimate gene expression noise from scRNA-seq data, accounting for technical noise and cell type heterogeneity, and demonstrates its reproducibility using yeast data.

This paper introduces a digital molecular kinetics platform using large-scale nanopore arrays to overcome limitations of traditional methods like SPR, enabling comprehensive thermodynamic-kinetic profiling and improved detection of molecular interactions.

The paper analyzes calcium binding properties of a cancer-linked calreticulin mutant and shows it retains low-affinity calcium binding and maintains ER calcium homeostasis.

This study uses a subject-specific musculoskeletal model to examine how load magnitude, height, and side affect spinal loading and muscle forces in adolescent idiopathic scoliosis.

This paper introduces a customizable bead-based platform for isolating and detecting specific EV populations in plasma, demonstrating sensitivity and the ability to distinguish clinically relevant biomarker expressions.

Open Blink provides a low-cost, open-source TIRF microscope for quantitative multi-color super-resolution imaging with high localization precision and axial stability.

This study examines immune cell changes in obesity and after bariatric surgery, finding preserved type 2 immune cell plasticity and differential immune recovery.

The paper experimentally determines subcellular localization of 234 metabolic enzymes in sorghum, providing a resource for metabolic organization studies.

The paper re-examines the SRX state in myosin using mant-ATP displacement assays and finds no evidence of the SRX state in isolated myosin but detects two components in myofibrils, suggesting distinct myosin populations in thick filaments.

This paper develops a high-sensitivity and high-throughput LC-MS workflow for low-input and single-cell proteomics, achieving high proteome depth and throughput without specialized equipment.

This study examines edge effects on termite fauna in a neotropical rainforest, finding no significant reduction in soil feeder presence but increased abundance of an opportunistic species at forest edges.

This study evaluates GuNA-modified ASOs, showing improved KD activity, long-term efficacy, and reduced toxicity in a mouse model.