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Matching Corticospinal and Cortical Excitability along the motor cortex: TMS-EMG-EEG study

This study investigates the relationship between cortical and corticospinal excitability thresholds along the motor cortex using TMS-EMG-EEG in 24 subjects, finding strong correlations and site-specific differences.

High-throughput sequencing of unmethylated DNA (UMR-seq) reveals extensive epigenetic variation in the hypomethylome of diverse plant species

UMR-seq reveals epigenetic variation in plant hypomethylomes, showing UMRs are enriched in regulatory loci and improve genomic prediction and trait association mapping in wheat.

Cross-cancer knowledge transfer for lymph node metastasis prediction: Applicability of an axillary lymph node-based deep learning model

This paper evaluates a deep learning model trained on axillary lymph nodes for predicting metastasis in lymph nodes from different anatomical regions across cancers.

The collective effect of non-nicotine constituents on the reinforcing and neuropharmacological effects of comprehensive cigarette smoke and electronic nicotine delivery system (ENDS) aerosol extracts in rats.

This study compares the reinforcing and neuropharmacological effects of cigarette smoke and e-cigarette aerosol extracts with nicotine in rats, finding that non-nicotine constituents in cigarette smoke contribute to these effects.

Computational Analysis of Antioxidant Effects on Stress Response Mechanisms in Candida albicans

The paper uses computational methods to analyze antioxidant effects on stress response mechanisms in Candida albicans, identifying naringenin and quercetin as potential modulators of Sir2/SIRT3 pathways.

Actin pool controls the scaling of dynamic actin networks

The paper investigates how actin networks scale with cell volume by reconstituting dynamic structures in controlled environments and shows that monomer depletion and disassembly rates determine scaling behavior.

Genetic disruption of cutaneous de novo glucocorticoid synthesis: a CRISPR-Cas9 CYP11B1-knockout human epidermal model

This paper creates a CRISPR-Cas9 CYP11B1-knockout human epidermal model to study the effects of blocking cutaneous glucocorticoid synthesis.

Chronic Sleep Disruption Activates the Transcriptional Unfolded Protein Response and Induces Compartment-Specific Proteomic Changes in Mice

This study shows chronic sleep disruption causes distinct transcriptional and proteomic changes in brain compartments, particularly affecting synaptic function and potentially contributing to Alzheimer's risk.

SQANTI-evidence: isoform-resolved, evidence-tiered structural annotation of unannotated genomes from long-read RNA-seq

SQANTI-evidence annotates genomes from long-read RNA-seq without a reference, achieving high precision in gene and isoform prediction across species.

Proteome-Wide Serology Identifies Secreted IgD against RSV Fusion Glycoprotein as a Signature of Broadly Elevated Antibody Response

The paper introduces ProWiSe, a mass spectrometry-based method to quantify antigen-specific antibodies, revealing elevated IgD levels against RSVF in maternal sera.

Auditing Biomedical Literature with Blinded AI Peer Review: Where Peer Review Works, Where It Fails, and How to Strengthen It

This paper evaluates the effectiveness of a blinded AI peer review system (BARS) in auditing biomedical literature, finding it improves consistency and detects flaws while highlighting issues with megajournals and template studies.

Comparative Transcriptomic Analysis of Gene Expression Patterns in Neutrophils from Rheumatoid Arthritis and COVID-19

This paper compares neutrophil transcriptomic profiles in rheumatoid arthritis and COVID-19 to identify shared immune pathways and disease-specific features.

Sex-specific growth in invasive pink salmon (Oncorhynchus gorbuscha) from two regions in northern Norway

This study examines sex-specific marine growth differences in invasive pink salmon from two Norwegian fjords, finding males from Varangerfjord had higher growth rates and body size than other groups.

Integrative Transcriptomic Meta-Analysis Reveals SIRT1-SNCA Correlation in Parkinson's Disease

This study identifies a context-dependent resveratrol-SIRT1 axis in Parkinson's disease through integrative transcriptomic analysis across multiple models.

Finely tuned DDA-PASEF-based immunopeptidomics workflow enhances HLA class I coverage

This study optimizes a DDA-PASEF-based immunopeptidomics workflow to enhance HLA class I peptide coverage in low-input samples.

Structural Basis for Human Milk Oligosaccharides Recognition by Evolutionarily Dominant Norovirus Genogroup II Genotypes

This study investigates how different norovirus genotypes recognize human milk oligosaccharides using structural and biochemical methods, revealing genotype-specific binding mechanisms.

A closed genome of Streptococcus agalactiae ST347/II reveals a composite integrative element coupling nisin P biosynthesis to erm(B) and tet(O) in Dominican group B Streptococcus

The paper closes the genome of a Dominican group B Streptococcus isolate, revealing a composite integrative element linking nisin P biosynthesis to antibiotic resistance genes.

Hazard Structure and Repair Kinetics: A 2x2 Classification that Resolves the Stochastic-Death / Individual-Tolerance Dilemma

The paper classifies hazard structures in toxicology models and identifies peak-based hazard as the appropriate default for certain toxicants.

Connectivity of Implicit Statistical Learning Networks is Associated with Language Impairment Severity in Post-Stroke Aphasia

This study examines how implicit statistical learning networks' connectivity relates to aphasia severity in post-stroke patients, finding stronger connectivity correlates with milder aphasia.

SeverYX: An ensemble framework for robust variant severity classification

SeverYX is an ensemble framework that classifies genetic variants into severity tiers, achieving high concordance with ClinVar and improving predictive accuracy through threshold optimization and additional predictors.