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Confidence: Its Measurement, Relation to Behavior, and Neural Representation

This study measures confidence through a decision-making task and finds it is a state influenced by environmental factors rather than a driver of behavior.

Creation of genomic chimeras via megabase scale genome expansion

This paper introduces ACE, a method to create genomic chimeras by integrating large genomic segments from donor cells into a recipient genome, demonstrating its ability to generate stable chimeric organisms across species barriers.

Extensional Flow Microfluidics Reveal Size-Dependent Core-Shell Mechanical Heterogeneity in Pancreatic Tumor Spheroids

This study uses microfluidics to show that pancreatic tumor spheroids of different sizes exhibit distinct mechanical behaviors, with larger spheroids showing core-shell heterogeneity.

stem.MAP: Identification of cell-type-specific protein complexes in mammalian embryonic stem cells.

The paper develops a proteomics-based machine learning workflow to identify cell-type-specific protein complexes in mouse embryonic stem cells, revealing 3,986 complexes and 1,388 unique interactions specific to mESC.

Moving Heads, Moving Sounds: Systematic Errors in Auditory Motion Perception

This study shows that head movements create a perceptual bias in the direction of a moving sound source, similar to visual motion illusions, revealing errors in integrating auditory and proprioceptive cues.

Quantitative live imaging reveals region-dependent medulloblastoma disseminationin the zebrafish brain

This study uses live imaging in zebrafish to show that hindbrain medulloblastoma cells spread more frequently than forebrain or midbrain tumors and that dasatinib reduces dissemination.

Primary vitamin B12 limitation and widespread stress in Antarctic phytoplankton

This study shows that vitamin B12, not iron, is the primary limiting nutrient for phytoplankton in the Southern Ocean, with implications for community composition and function.

Active site electrostatic effects modulate DBO inhibitor potency against OXA-48 variants

This paper investigates how electrostatic effects in the active site influence the potency of DBO inhibitors against OXA-48 variants using computational simulations.

Tools for genetic mapping and gene identification in Caenorhabditis briggsae

The paper updates a toolkit for genetic studies in C. briggsae by identifying indel variants and mapping mutations to genes using high-throughput sequencing.

A biomimetic deep encoder for auditory restoration by cortical stimulation

This paper introduces Braincodec, a deep encoder that improves sound transmission via cortical stimulation, achieving high-fidelity sound reconstruction and matching non-implanted mice in sound discrimination.

Coarse-graining genome-scale metabolic models for dynamic, multi-scale simulations of Pseudomonas aeruginosa in gel environments

This paper introduces GEM-CM, a computational framework that couples reaction-diffusion models with genome-scale metabolic models to simulate Pseudomonas aeruginosa growth and pyocyanin production in agar gels.

MitoDecode: quantitative phenotypic decoding of mitochondrial stress states from fluorescence images

MitoDecode assesses mitochondrial stress types and severity from fluorescence images without segmentation, showing adaptability across cell types and stress conditions.

Evaluating non-oxidative glycolysis using 13C metabolic flux analysis

This study evaluates the precision of 13C metabolic flux analysis using different glucose tracers to estimate non-oxidative glycolysis fluxes in E. coli.

Body size cascades from Neodiprion sawfly hosts to Perilampid parasitoids: An investigation of sequential divergence

The paper investigates whether parasitoid body size and morphology diverge in response to host species differences in Neodiprion sawflies, supporting sequential divergence.

Increased Cognitive Load Expands, Stabilizes, and Aligns Visual Representation Across the Human Brain

This study shows that increased cognitive load expands and stabilizes visual representations across the brain, enhances cross-regional coordination, and reduces neural variability.

Generative Models for Novel Enzymatic Reactions: How Far Do They Go?

This paper evaluates generative models for predicting novel enzymatic reactions, finding they can generate correct reactions for 25% of test cases and improve over existing methods.

Phase-locked dual-band vibration bursts strengthen anti-kindling by vibrotactile coordinated reset stimulation in a spiking network model

The paper shows that a dual-band vibration burst improves anti-kindling in a spiking network model compared to single-frequency stimulation.

Amyloid stability and condensate material properties independently govern the hnRNPA2 condensate to fibril transition

This study shows that amyloid structure and condensate stability independently influence the hnRNPA2 condensate-to-fibril transition, revealing a structural framework for this process.

Widespread Saccharomyces hybridization in agave fermentations arises repeatedly from asymmetric parental diversity

The paper identifies widespread Saccharomyces hybridization in agave fermentations, showing multiple independent origins and asymmetric parental genetic diversity.

Deep transcriptomic analysis of molecular mediators of complex traits in heterogeneous stock (HS) rats

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.