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Targeting REV1 Exposes Context-Dependent Therapeutic Responses in Colorectal Cancer

This study shows that targeting REV1 in colorectal cancer enhances chemotherapy sensitivity in a context-dependent manner and inhibits organoid growth.

Hierarchical Temporal Transformer for Cancer Grade Prediction and Cross-Cancer Transfer Learning from Pathology Reports

This paper introduces a hierarchical temporal transformer for cancer grade prediction from pathology reports, showing improved performance across cancer types and using visit timing when identifiable.

Learning Strand-Equivariant Tokenizations of DNA with MirrorDNA

This paper introduces MirrorDNA, a DNA language model with a strand-equivariant tokenizer that improves prediction consistency across DNA strands.

Distributed Network Sensing as an Escape Strategy

The paper shows that slime mould networks can detect and escape harmful environments through reconfiguration, depending on their size and connectivity.

An expansive internal chemosensory system in the insect abdomen implicates Gustatory Receptors in diverse aspects of interoception

This study identifies an internal chemosensory system in Drosophila melanogaster's abdomen using Gustatory Receptors, revealing new roles in interoception beyond traditional feeding behaviors.

Galectin-9 drives thrombo-inflammatory circuits initiating venous thrombosis

This study identifies Galectin-9 as a driver of venous thrombo-inflammation, linking inflammation to thrombus formation through platelet activation and NETosis.

A biological light sheet links cellular voltage to mesoscopic brain dynamics

This paper introduces SPress, a method that enables high-speed, high-contrast voltage imaging of large neuronal populations in vivo with mesoscopic resolution.

MOCHI enables systematic identification of candidate independent intronic transcriptional signals from short-read RNA-seq data

MOCHI identifies candidate independent intronic transcripts from short-read RNA-seq data, revealing novel transcripts associated with cancer survival.

A single-cell transcriptomic atlas of paper wasp brains highlights Kenyon cells' role in social behavior

The paper uses single-cell transcriptomics to analyze brain cells in paper wasps, showing that Kenyon cells vary with social roles and respond to social interactions.

Can a Tiny Brain Plan? Reconstructing a Predatory Detour inthe Jumping Spider Portia labiata

This study reconstructs a wild hunt of a jumping spider, suggesting it may have planned its route to avoid detection by prey.

Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

Hub labeling makes exact distance calculation practical for large human pangenome graphs

The paper introduces a hub labeling method to reduce the space required for distance indexing in large pangenome graphs, improving query support and reducing storage needs.

TGF-b/TIF1g signaling restrains CD8+ T cell expansion while preserving cytotoxic competence

This study identifies TIF1g as a regulator of TGF-b signaling in CD8+ T cells, showing it restricts expansion while preserving cytotoxic function.

Brief visual oddball events evoke CSF flow in the spinal canal

The paper measures CSF flow in the spinal canal using fMRI and finds it correlates with BOLD activity decreases and is provoked by visual oddball stimuli.

Continental scale genetic diversity supports geo-clustered ecoregions connectivity

The paper examines genetic diversity and connectivity between ecoregions, finding a divide between eastern and western regions with restricted gene flow in the west.

Assessing Enclosure Modifications to Enhance Accessibility for Zoo-Housed Meerkats (Suricata suricatta)

This study evaluates how accessibility modifications in zoo enclosures affect meerkat behavior, finding increased use of low areas and more frequent species-appropriate sentry behavior.

2'-O-Methylated ncRNA condensates form a recombination center for IgH synapsis

This study shows that FBL-mediated 2'-O-methylation of GLTs forms condensates that drive IgH synapsis and CSR in B cells.

Distinct lifespan trajectories of cortical intrinsic timescales and neural oscillations

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

Genomic and Epigenomic Relationships Capture Different Patterns of Genotype-by-Environment Interaction in Grapevine Clones

This study compares how genomic and epigenomic relationships contribute to genotype-by-environment interaction in grapevine clones, finding that epigenomic factors capture more GEI variance than genomic factors.

PARP1-mediated PARylation of SPRTN restrains its DNA-protein crosslink repair activity

This study shows PARP1-mediated PARylation of SPRTN limits its DNA-protein crosslink repair activity by reducing DNA binding and proteolytic function.