Discover, rate, and discuss biology preprints.

This paper introduces a method to cluster instantaneous phase-locking states using the Bures-Wasserstein distance, improving sensitivity to phase-lag size and spatial patterns in EEG data.

This study shows that non-homologous end joining (NHEJ) facilitates rapid adaptation to caspofungin in Nakaseomyces glabratus by enabling FKS2 mutations, while NHEJ-deficient strains adapt less efficiently through alternative pathways.

PixAQ improves single-cell protein quantification in imaging mass cytometry by assigning pixel signals to specific markers using spatial and intensity models.

The paper uses fMRI and a deep neural network to assess memory maturation in children aged 3-7, finding that hippocampal development drives memory pattern maturation.

The paper shows that human observers can improve color discrimination by tilting surfaces to sample directional lighting, rather than relying on uniform illumination.

NORMA 3.0 provides enhanced visualization and analysis of annotated biological networks with improved group representation and layout algorithms.

The paper identifies a uORF, PHYRE, essential for phytochrome B translation and photomorphogenesis in Arabidopsis, showing its role in translational regulation.

This study investigates the functional impact of a DNM1L GED deletion variant, showing intermediate effects on peroxisomal and mitochondrial dynamics and a targetable metabolic vulnerability.

This study shows Escherichia coli has an intrinsic timekeeping system that anticipates daily temperature cycles through rhythmic curli plaque formation.

The paper benchmarks cryo-EM re-refinement selection methods against no operation using a fixed cohort and scoring tools, finding increased disagreement with higher-resolution references.

TensorPLS is an R package for analyzing longitudinal omics data using PLS-DA, handling missing data and providing temporal insights through VIP scores and cross-validation.

This paper introduces an end-to-end in silico framework to validate and test clinical genome sequencing pipelines from simulated reads to reportable findings using a fixed truth set.

The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.

This paper evaluates optimiser repairs in living-cell self-driving labs, showing when they improve performance and when constraints make them redundant.

CRISP identifies and localizes interactions between biological signals in single-cell and spatial transcriptomic data, revealing their effects on tissue function and gene regulation.

This paper identifies a new mode of chromosome-end instability in cancer using circular DNA analysis, revealing a distinct spatial signature called EDGE.

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

This study identifies Mif as an oocyte-stored protein that promotes preimplantation embryo development through extracellular signaling, showing its role in blastocyst growth and density-dependent effects.

The paper identifies a second PspA/VIPP1 system in Gammaproteobacteria, characterized by YjfJ-like proteins, which are prevalent and functionally distinct from the canonical PspA system.