K. Takeuchi

Inosine Triphosphate Pyrophosphatase as a Candidate Associated with White Matter Abnormalities in Chronic Heart Failure

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

Atlas of Cynomolgus Macaque Hematopoiesis

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

A mouse model of insomnia with sleep apnea

This paper develops a mouse model of comorbid insomnia and sleep apnea (COMISA) by inducing daytime hypoxia, showing a down-and-up activity response linked to sleepiness and insomnia.

Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

Subcellular localization of glypican-5 associates with dynamic cell motility and cell communication of the human mesenchymal stem cell line U3DT

The paper investigates the subcellular localization of GPC5 in U3DT cells and links its distribution to cell motility and communication.

Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex

This study reports the crystal structure of the human condensin I subcomplex hCAP-G and hCAP-H, revealing their interaction and DNA binding capabilities essential for mitotic chromosome assembly.