Laetitia Maroc

This paper optimizes dCas12a-based CRISPRi/a for pooled screening in Yarrowia lipolytica, identifying effective crRNA features and a high-performing effector variant.

This study shows that non-homologous end joining (NHEJ) facilitates rapid adaptation to caspofungin in Nakaseomyces glabratus by enabling FKS2 mutations, while NHEJ-deficient strains adapt less efficiently through alternative pathways.

The paper curates AMR mutations in fungi to create FungAMR, identifies universal resistance mutations, and provides a tool to screen genomes for AMR mutations.

This study investigates the role of REV1, an error-prone polymerase, in DNA damage and antifungal drug resistance in Candida albicans, finding that its deletion increases mutation rates and resistance.

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

This paper develops and validates a CRISPR activation system in Nakaseomyces glabrata to study gene overexpression in pathogenesis and drug resistance.

The paper investigates the role of H3K27me3 and H3K9me3 histone modifications in the fungus Podospora anserina, showing their distinct functions in development and gene silencing.

The paper shows that a single Ho-induced DSB at MAT is lethal in C. glabrata, but CRISPR-Cas9 can trigger mating-type switching without high lethality.