A. A. Khan

TRIBAL: Tree Inference of B cell Clonal Lineages

TRIBAL infers B cell lineage trees from scRNA-seq data by integrating isotype information, improving accuracy in capturing somatic mutations and class switch dynamics.

Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction

This study establishes a hamster model of Trypanosoma cruzi infection using bioluminescence imaging, revealing chronic tissue pathology and motor dysfunction not seen in mice.

Comparative Analysis, Diversification and Functional Validation of Plant Nucleotide-Binding Site Domain Genes

This study identifies and classifies NBS domain genes across 34 plant species, revealing structural diversity and functional roles in plant-pathogen interactions.

Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy

This study shows that curative treatment with benznidazole at 6 weeks post-infection reverses digestive Chagas disease symptoms in mice, while delayed treatment leads to irreversible damage.

Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

This study shows that gut commensal bacteria enhance MuLV-induced leukemia by suppressing the adaptive immune response through upregulation of immune regulators.

Dysfunctional Senescent Herpes Simplex Virus Specific CD57+CD8+ T cells are Associated with Recurrent Symptomatic Herpes in Humans

The paper identifies dysfunctional senescent HSV-specific CD8+ T cells in symptomatic herpes patients compared to asymptomatic individuals, linking senescence to recurrent herpes susceptibility.

Assessing the Live Decellularized Renal Microvasculature Post-Transplantation using Intravital Microscopy

This study uses intravital microscopy to assess microvascular integrity in decellularized renal scaffolds post-transplantation in rats, showing initial structural retention and progressive permeability issues.

Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

This study quantifies NPC density and distribution in S. pombe nuclei using structured illumination microscopy, revealing NPC exclusion around the nucleolus and SPB and its dependence on Lem2-mediated centromere tethering.

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

The paper identifies chronic T. cruzi infection foci in the colon linked to enteric neuropathic lesions, suggesting chemotherapy could prevent chronic disease.

Intravital imaging of real-time endogenous actin dysregulation in proximal and distal tubules at the onset of severe ischemia-reperfusion injury

This study uses intravital imaging to observe real-time actin dysregulation in kidney tubules during severe ischemia-reperfusion injury in rats.

Interaction of an abiraterone with calf thymus DNA: Investigation with spectroscopic technique and modeling studies

This study investigates how abiraterone binds to calf thymus DNA using spectroscopy and modeling, finding minor groove binding with hydrogen bonding as the main interaction force.

Factors Affecting Detection Of GMO Traces In Food And Crop Samples

This study examines factors affecting the detection of GM rice, showing that husk presence, DNA extraction methods, and PCR primers significantly influence detection outcomes.

Evolutionary history of Alzheimer Disease causing protein family Presenilins with pathological implications.

This study investigates the evolutionary history of Presenilins, showing they originated in the last common eukaryotic ancestor and are under strong purifying selection, with mutations linked to Alzheimer's disease.