M. Saeed

Simultaneous detection of membrane contact dynamics and associated Ca2+ signals by reversible chemogenetic reporters

The paper introduces PRINCESS, a novel biosensor that simultaneously detects membrane contact sites and measures associated Ca2+ dynamics using splitFAST technology.

Comparative Analysis, Diversification and Functional Validation of Plant Nucleotide-Binding Site Domain Genes

This study identifies and classifies NBS domain genes across 34 plant species, revealing structural diversity and functional roles in plant-pathogen interactions.

Soft robotics-enabled large animal model of HFpEF hemodynamics for device testing

This paper develops a porcine model of HFpEF hemodynamics using soft robotic sleeves to test medical devices, showing consistent results with in silico and clinical data.

High dimensional analyses reveal activation of lymphocyte subsets and reversal of immunoresistance by cytokine enhancement of adoptive cellular vaccine therapy in prostate cancer.

This study shows IL-15 treatment enhances the anti-tumor efficacy of sipuleucel-T by increasing CD8+ T-cell and CD56+ NKT subset activity in prostate cancer.

The HLA-II immunopeptidome of SARS-CoV-2

The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions

This study identifies additional host proteins involved in SARS-CoV-2 entry using a novel photocatalytic mapping platform called ViraMap.

Immunomodulatory effects of Simvastatin in Toll-like receptor-2 stimulated Rheumatoid arthritis synoviocytes

This study shows simvastatin induces apoptosis in rheumatoid arthritis synoviocytes by upregulating BNIP3 and inhibiting Akt, while increasing IL-6 and antioxidant gene expression.

Susceptibilities of human ACE2 genetic variants in coronavirus infection

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

SARS-CoV-2 Requires Cholesterol for Viral Entry and Pathological Syncytia Formation

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway

This study identifies SARS-CoV-2 inhibition of the JAK-STAT pathway as a mechanism to suppress interferon signaling across diverse cell types.

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

LY6E impairs coronavirus fusion and confers immune control of viral disease

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

The Effect Of Famotidine On SARS-CoV-2 Proteases And Virus Replication

This study investigates famotidine's effect on SARS-CoV-2 proteases and virus replication, finding no direct inhibition of 3CLpro, PLpro, or viral replication at high concentrations.

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.