Author

M. Fischbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Chervonsky· 2 shared J. Spring· 2 shared T. Golovkina· 2 shared A. A. Khan· 1 shared A. Jacobson· 1 shared A. N. Jacobson· 1 shared B. Allen· 1 shared B. C. DeFelice· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Chervonsky

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Retroviral infection and commensal bacteria dependently alter the metabolomic profile in a sterile organ

J. Spring, V. Beilinson, B. C. DeFelice, J. M. Sanchez, M. Fischbach, A. Chervonsky, T. Golovkina

bioRxiv · Jan 10, 2023Microbiology

Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus

J. Spring, S. Lara, A. A. Khan, K. O'Grady, J. Wilks, S. Gurbuxani, S. Erickson, M. Fischbach, A. Jacobson, A. Chervonsky, T. Golovkina

This study shows that gut commensal bacteria enhance MuLV-induced leukemia by suppressing the adaptive immune response through upregulation of immune regulators.

bioRxiv · Feb 2, 2022Microbiology

CRISPR-based functional genomics in human dendritic cells

M. Jost, A. N. Jacobson, J. A. Hussmann, G. Cirolia, M. Fischbach, J. S. Weissman

This study develops a CRISPR/Cas9 method for human dendritic cells, enabling efficient gene knockouts and revealing mechanisms of immune response tuning to microbiome lipopolysaccharides.

bioRxiv · Dec 22, 2020Immunology

Bile acid metabolites control Th17 and Treg cell differentiation

S. Hang, D. Paik, S. Devlin, T. Jamma, J. Lu, S. Ha, B. Nelson, S. Kelly, L. Wu, Y. Zheng, F. Rastinejad, M. Krout, M. Fischbach, D. Littman, J. Huh

This study identifies two bile acid metabolites that regulate Th17 and Treg cell differentiation through distinct mechanisms, affecting immune balance in mice.

bioRxiv · Nov 8, 2018Immunology

Depletion of microbiome-derived molecules in the host using Clostridium genetics

C.-J. Guo, B. Allen, K. Hiam, D. Dodd, W. van Treuren, S. Higginbottom, C. Fischer, J. Sonnenburg, M. Spitzer, M. Fischbach

This study develops a genetic method to disable Clostridium species and investigates the impact of microbiome-derived molecules on host IgA modulation.

bioRxiv · Aug 27, 2018Microbiology