Cancer BiologybioRxivPreprint
Geldanamycin inhibits Jumonji histone lysine demethylase KDM4 and targets chimeric transcription factor PAX3-FOXO1
A. Abu-Zaid, S. Singh, W. LIN…·J. YANG
This study identifies geldanamycin and its analog 17-DMAG as dual KDM/Hsp90 inhibitors effective against PAX3-FOXO1-driven rhabdomyosarcoma.
DOI 10.1101/2019.12.11.872838