W. Lin

Effects of clinically relevant radionuclides on the activation of a type I interferon response by radiopharmaceuticals in syngeneic murine tumor models

This study examines how different radionuclides affect the type I interferon response in tumor models and shows that 225Ac enhances immunotherapy response via STING-dependent mechanisms.

A long non-coding RNA LINC00094 regulates the transcriptional expression of lipid metabolism-related genes as a new member of core regulatory circuitry in esophageal squamous cell carcinoma

This paper identifies LINC00094 as a long non-coding RNA that forms a core regulatory circuitry with TCF3 and KLF5 to regulate lipid metabolism-related genes in esophageal squamous cell carcinoma.

Hierarchical global and local auxin signals coordinate cellular interdigitation in Arabidopsis

The paper shows auxin signaling coordinates cell shape in Arabidopsis through global and local pathways involving TIR1/AFB and TMK.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

The under-recognized dominance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater ecosystems

The paper identifies a high abundance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater environments, revealing Deltaproteobacteria as dominant rather than Magnetococcia.

Riluzole reverses blood-testis barrier loss to rescue chemotherapy induced male infertility by binding to TRPC

This study shows riluzole restores blood-testis barrier function and rescues chemotherapy-induced male infertility in mice by targeting TRPC5.

Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC

The paper introduces a sensitive fluorescent biosensor, ExRai-CKAR2, to study subcellular PKC activity and finds differential regulation of PKC isoforms at the ER, lysosomes, and Par complexes.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Light-gated Integrator for Highlighting Kinase Activity in Living Cells

This paper introduces KINACT, a light-gated tool that converts kinase activity into permanent fluorescent marks for analyzing kinase dynamics and signaling mechanisms.

Protein SUMOylation promotes cAMP-independent EPAC1 activation

This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.

DFNA5-mediated pyroptosis is a driver for venetoclax and azacytidine synergy in myeloid leukemia

This study shows that DFNA5-mediated pyroptosis contributes to the synergy between venetoclax and azacytidine in myeloid leukemia, beyond apoptosis.

Quantitative Learning of Cellular Features From Single-cell Transcriptomics Data Facilitates Effective Drug Repurposing

This study introduces SuperFeat, a framework that uses single-cell transcriptomics data to identify drug targets by modeling adverse cellular states, validated in vitro and in vivo.

Eyes on nature: Embedded vision cameras for multidisciplinary biodiversity monitoring

The paper introduces a portable, low-power embedded vision camera system for biodiversity monitoring, demonstrating its application across multiple ecological disciplines with classification accuracies between 55% and 96%.

Co-opted cytosolic host proteins form unique condensate substructures within the membranous tombusviral replication organelles

This study shows that tombusvirus replication proteins form condensate substructures within membranous replication organelles, which are critical for ATP production and viral replication.

Reciprocal polarization imaging of complex media.

This paper introduces reciprocal polarization imaging to quantify anisotropic properties of complex media using backscattering Mueller matrices, demonstrating its effectiveness in various applications.

NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma

The paper identifies NDC80 as a predictor of ccRCC progression and shows that NDC80-high tumors are sensitive to mitotic kinase inhibitors.

Light sheet autofluorescence lifetime imaging with a single photon avalanche diode array

This paper introduces a light sheet FLIM system using SPAD arrays for fast, label-free single-cell NAD(P)H autofluorescence imaging in live cells and organisms.

Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

Spatial-temporal evolution characteristics of land use and its driving factor analysis during the period of 2000-2020 in Putian City, Fujian Province

This study analyzes land use changes and driving factors in Putian City from 2000 to 2020 using remote sensing data and statistical methods.

A GFP splicing reporter in a coilin mutant background reveals links between alternative splicing, siRNAs and coilin function in Arabidopsis thaliana

The paper uses a GFP splicing reporter in a coilin mutant to show that coilin affects alternative splicing, siRNA production, and gene silencing in Arabidopsis.

ABLs and TMKs are co-receptors for extracellular auxin

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

Response of sugarcane rhizosphere soil fungal communities on a temporal gradient to changes in critical growth periods

This study examines how sugarcane rhizosphere fungal communities change over time, identifying key fungal genera and environmental drivers affecting their structure and disease risk.

Thermophoresis of Molecules and Structures of different Sizes in Self-assembled Biomatrices

The paper studies thermophoresis of various biomolecules in self-assembled matrices, showing enhanced thermodiffusion due to surrounding network effects.

Prospective Motion Correction and Automatic Segmentation of Penetrating Arteries in Phase Contrast MRI at 7 T

This paper develops a prospective motion correction method for 7 T phase contrast MRI of penetrating arteries and evaluates its effectiveness using CNN-based segmentation.

Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

This study shows Epac1 regulates SUMOylation by forming nuclear condensates in response to cAMP, linking stress responses to SUMOylation dynamics.

MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FoxO1 protein complex

This study identifies miR-144 as a regulator of adipogenesis by mediating the formation of the C/EBPα-FoxO1 protein complex, which influences AdipoQ expression and adipocyte differentiation.

Eicosanoids in the pancreatic tumor microenvironment: a multicellular, multifaceted progression

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

Genomically hardwired regulation of gene activity orchestrates cellular iron homeostasis in Arabidopsis

The paper shows that gene activity in Arabidopsis under Fe deficiency is regulated by transcription and alternative splicing, with genomic features influencing which regulatory mode is used.