Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis
N. J. Lang, J. Gote-Schniering, D. Porras-Gonzalez, L. Yang, L. J. De Sadeleer, R. C. Jentzsch, V. Shitov, S. Zhou, M. Ansari, A. Agami, C. H. Mayr, B. Hooshiar Kashani, Y. Chen, L. Heumos, J. C. Pestoni, , H. B. Schiller
The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.
bioRxiv · Jan 16, 2023 · PreprintCell Biology