M. Ansari

Cell circuits underlying nanomaterial specific respiratory toxicology

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis

The paper uses ex vivo perturbations on human lung slices combined with single-cell RNA-seq to study fibrogenesis, showing similarities to in vivo cell circuits and drug effects.

An efficient method to generate fluorescent amyloid fibrils

This paper introduces a method to generate fluorescent amyloid fibrils using non-covalent fluorophore incorporation, enabling monitoring of cellular internalization and interfibrillar interactions without altering fibril structure.

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era

The paper shows that pre-COVID-19 individuals had genetic TCR repertoire and HLA variants capable of recognizing SARS-CoV-2 infected cells.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

An integrated cell atlas of the human lung in health and disease

The paper integrates 46 single-cell datasets to create the Human Lung Cell Atlas, improving cell annotation and uncovering gene modules linked to demographics and anatomy.

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary Fibrosis

The paper identifies GPR87 as a novel marker for KRT5+ basal cells in IPF distal bronchioles and honeycomb cysts using single-cell RNA sequencing.

A transcriptomics-guided drug target discovery strategy identifies novel receptor ligands for lung regeneration