A. Gao

Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

This study shows that TMAO, a microbial metabolite, enhances C. jejuni infection by increasing intestinal inflammation, epithelial damage, and barrier disruption.

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

Colonic spermidine promotes the proliferation and migration of intestinal epithelial cells.

This study shows that colonic spermidine, produced by B. uniformis, promotes intestinal epithelial cell proliferation and migration during gut repair.

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas

This study investigates the relationship between CDKN2A mRNA expression and clinical outcomes in meningiomas, finding that high expression is associated with poorer progression-free survival and more aggressive tumor characteristics.

Serotyping Salmonella Enteritidis and Typhimurium Using Whole Cell Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry (MALDI-TOF MS) through Multivariate Analysis and Artificial Intelligence

This study uses MALDI-TOF MS and AI to accurately serotype Salmonella strains, achieving 100% correct identification of Enteritidis, Typhimurium, and other serovars.

Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L

This study determines the structure of SARS-CoV-2 Mpro with calpain inhibitors and analogues, revealing new insights for developing dual inhibitors against Mpro and cathepsin L.

Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2

The paper presents a physics-based model predicting T cell epitope immunogenicity across pathogens, finding that only some SARS-CoV-2 epitopes are immunogenic and some are shared with low-pathogenicity coronaviruses.

Microscaled Proteogenomic Methods for Precision Oncology

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

Identification of key pathways and metabolic fingerprints of longevity in C. elegans

This study identifies shared metabolic pathways and signatures of longevity in C. elegans by integrating transcriptomics and metabolomics data from IIS and CR models.