Author

A. Auerbach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Cheng· 2 shared D. Indurthi· 2 shared S. N. Moraes· 2 shared B. Stefanovska· 1 shared C. J. Bierle· 1 shared D. C. Indurthi· 1 shared E. Fanunza· 1 shared J. Becker· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

A. Cheng

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Author profile →

6 papers

Recent·Most cited

Conformational dynamics of a nicotinic receptor neurotransmitter site

M. Singh, D. C. Indurthi, L. Mittal, A. Auerbach, S. Asthana

The paper uses molecular dynamics simulations to study conformational changes in a nicotinic receptor site induced by agonists, identifying key steps in the low-to-high affinity transition.

bioRxiv · Sep 16, 2023 · PreprintBiophysics

Efficiency of an allosteric protein: Multiple affinity-efficacy correlations link agonist binding to nicotinic receptor activation

D. Indurthi, A. Auerbach

The paper quantifies efficiency as the correlation between agonist affinity and efficacy in nicotinic receptors, revealing five distinct efficiency classes across multiple agonists and mutations.

eLife · Jul 3, 2023Peer-reviewedBiophysics

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism

R. S. Harris, E. Fanunza, A. Cheng, A. Auerbach, B. Stefanovska, S. N. Moraes, J. Lokensgard, M. Biolatti, V. Dell'Oste, C. J. Bierle, W. A. Bresnahan

This paper shows that human cytomegalovirus (HCMV) relocalizes APOBEC3B from the nucleus to the cytoplasm through an RNR-independent mechanism, unlike related herpesviruses.

bioRxiv · Jan 30, 2023Microbiology

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

S. N. Moraes, J. Becker, S. A. Moghadasi, N. Shaban, A. Auerbach, A. Cheng, R. Harris

The paper investigates how gamma-herpesvirus ribonucleotide reductases antagonize APOBEC3B, showing conservation across human and Old World monkey-infecting viruses but not New World monkey-infecting viruses.

bioRxiv · Apr 4, 2022Microbiology

Agonists to ions: Efficiency suggests a 'zipper' mechanism for nicotinic receptor activation

A. Auerbach

The paper examines agonist efficiency in nicotinic receptors, finding it correlates with affinity and efficacy, suggesting a zipper-like mechanism of domain rearrangement during activation.

bioRxiv · Dec 18, 2021 · PreprintBiophysics

Agonist efficiency from concentration-response curves: structural implications and applications

D. Indurthi, A. Auerbach

The paper calculates agonist efficiency from concentration-response curves and shows it relates to agonist size and binding site mutations.

bioRxiv · Oct 13, 2020 · PreprintBiophysics