J. Becker

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

The paper maps treatment-associated changes in the tumor immune microenvironment using single-cell RNA sequencing and identifies transition patterns that predict response to checkpoint inhibitor therapy.

Partitioning biota along the Elbe River estuary: where are the community transitions?

The paper examines community transitions in the Elbe River estuary, finding two distinct communities for plants and soil bacteria but not for aquatic microbes.

A quantitative description for optical mass measurement of single biomolecules

The paper develops a framework for light-based single molecule detection and quantification by simulating mass photometry experiments using Fourier optics and molecular polarizability models.

Fasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism

This study shows that SUMOylation of Prox1 regulates hepatic cholesterol metabolism in response to fasting, with implications for metabolic health.

Sinking a giant: quantitative macroevolutionary comparative methods debunk qualitative assumptions

The paper responds to criticisms of their subaqueous foraging inferences for spinosaurids, showing that additional analyses do not alter their original conclusions.

Impaired immune response drives age-dependent severity of COVID-19

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

The paper investigates how gamma-herpesvirus ribonucleotide reductases antagonize APOBEC3B, showing conservation across human and Old World monkey-infecting viruses but not New World monkey-infecting viruses.

Establishment of a reverse genetic system from a bovine derived Influenza D virus isolate.

This paper establishes a reverse genetic system for a bovine Influenza D virus isolate to study its host tropism.

Comparative transcriptomic analysis reveals conserved transcriptional programs underpinning organogenesis and reproduction in land plants

This study generates gene expression atlases for 10 plant species to identify conserved transcriptional programs in organogenesis and reproduction, revealing gene co-option as a key mechanism for organ evolution.

Direct Supercritical Angle Localization Microscopy for Nanometer 3D Superresolution

This paper introduces SALM, a 3D superresolution technique that improves z-resolution by four times using direct splitting of supercritical and undercritical emission.

PSF broadening due to fluorescence emission

The paper quantifies PSF broadening due to fluorescence emission and proposes a method to reduce it by splitting the emission spectrum and recombining data in Fourier space.

Kingdom-wide comparison reveals conserved diurnal gene expression in Archaeplastida

The paper compares diurnal gene expression across nine Archaeplastida species, finding conserved transcriptional programs despite evolutionary divergence and lifestyle differences.