A. P. van Loon

Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation state

The paper uses CRISPRi screens in human neutrophils to identify genes regulating context-dependent migration and differentiation.

Cell surface receptors TREM2, CD14 and integrin αMβ2 drive sinking engulfment in phosphatidylserine-mediated phagocytosis

This study identifies TREM2, CD14, and integrin αMβ2 as essential cell surface receptors for PS-mediated phagocytosis, revealing distinct mechanisms for PS and antibody-coated target uptake.

Cortical myosin minifilaments orchestrate the arrangement of microridge protrusions on epithelial cell surfaces

The paper investigates how cortical myosin II minifilaments drive microridge fission and fusion in zebrafish larvae, leading to ordered arrangement of these protrusions.

Keratins and Plakin family cytolinker proteins control the length of epithelial microridge protrusions

The paper shows Keratin intermediate filaments and Plakin family proteins regulate microridge protrusion length in zebrafish epithelial cells by interacting with actin filaments.

Cortical contraction drives the 3D patterning of epithelial cell surfaces

The paper shows how cortical contractions drive the formation of microridges on zebrafish skin cells by reducing membrane tension and promoting precursor fusion.

The Drosophila Formin Fhod Nucleates Actin Filaments

This study shows that Drosophila Fhod nucleates and bundles actin filaments, unlike mammalian FHOD1 and FHOD3 which do not accelerate actin assembly.