Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
M. Doimo, S. Abrahamsson, V. L'Hote, M. Ndi, R. N. Das, K. Aasumets, A. Berner, S. Goffart, J. L. O. Pohjoismäki, M. Davila, E. Chorell, S. Wanrooij
The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.
bioRxiv · Jun 8, 2022Cell Biology