Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways
Y. Wang, T. Kroll, L. Hao, A. Sharma, V. Zhou, L. Moat, J. Mayer, S. S. Shukla, S. Hebbring, S. Guo, M. Iden, A. Bissonnette, G. Ananiev, D. Parashar, J. S. Rader, , Z. Wen
This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.
bioRxiv · Dec 26, 2023 · PreprintCancer Biology