Author

T. Kroll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

G. E. Borgstahl· 2 shared J. Azadmanesh· 2 shared K. L. Weiss· 2 shared K. Slobodnik· 2 shared L. Coates· 2 shared W. E. Lutz· 2 shared A. Bissonnette· 1 shared A. Natarajan· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

G. E. Borgstahl

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

J. Azadmanesh, K. Slobodnik, L. R. Struble, E. A. Cone, M. Dasgupta, W. E. Lutz, S. Kumar, A. Natarajan, L. Coates, K. L. Weiss, D. Myles, T. Kroll, G. E. Borgstahl

This study investigates the role of Tyr34 in MnSOD catalysis using neutron diffraction, X-ray spectroscopy, and quantum chemistry calculations, revealing its impact on proton-coupled electron transfer.

bioRxiv · May 29, 2024 · PreprintBiochemistry

Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

J. Azadmanesh, K. Slobodnik, L. Struble, W. E. Lutz, L. Coates, K. L. Weiss, D. A. A. Myles, T. Kroll, G. E. Borgstahl

The paper investigates the mechanism of product inhibition in human MnSOD by combining neutron diffraction and X-ray absorption spectroscopy to determine the atomic and electronic structures of the enzyme in different states.

bioRxiv · Jan 26, 2024Biochemistry

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

Y. Wang, T. Kroll, L. Hao, A. Sharma, V. Zhou, L. Moat, J. Mayer, S. S. Shukla, S. Hebbring, S. Guo, M. Iden, A. Bissonnette, G. Ananiev, D. Parashar, J. S. Rader, , Z. Wen

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

bioRxiv · Dec 26, 2023 · PreprintCancer Biology

Isolation, omics characterization and organotypic culture of alveolar type II pulmonary epithelial cells

H. Li, M. Schuette, M. Bober, T. Kroll, L. Frappart, G. Bou About, Y.-C. Lin, T. Sorg, Y. Herault, C. Wierling, O. Rinner, B. M. Lange, A. Ploubidou

This study isolates and characterizes alveolar type II cells using multi-omics and establishes a method for their organotypic culture.

bioRxiv · Aug 19, 2021 · PreprintCell Biology