Z. Wen

Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

Conservation of the ancestral function of GTSF1 in transposon silencing in unicellular Paramecium

This study shows that GTSF1 functions as a PIWI cofactor in transposon silencing in the unicellular eukaryote Paramecium, conserving an ancestral role observed in metazoans.

Epoxyeicosatrienoic acids and sEH inhibition prevent cardiac dysfunction in CVB3-induced myocarditis by positively regulating type I interferon signaling

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

Serial Capture Affinity Purification and Integrated Structural Modeling of the H3K4me3 Binding and DNA Damage Related WDR76:SPIN1 Complex

The paper uses SCAP to isolate the WDR76:SPIN1 complex, identifies H3K4me3 binding, and shows its role in DNA damage response through structural modeling and interaction network analysis.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

The Respiratory Syncytial Virus G Protein Enhances the Immune Responses to the RSV F Protein in an Enveloped Virus-like Particle Vaccine Candidate

This study shows that RSV VLPs containing both F and G proteins induce stronger neutralizing antibodies and better protection than VLPs with only F or only G proteins.

Genomic and transcriptional profiling stratifies VQ myeloma lines into two clusters with distinct risk signatures and drug responses

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

The Mitochondrial RNA Granule Modulates Manganese-Dependent Cell Toxicity

This study identifies the mitochondrial RNA granule as a protective mechanism against manganese toxicity by showing its downregulation enhances cell survival.

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

In vivo CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

This paper introduces an amorphous nickel-titanium alloy film as a new supporting substrate for cryoEM, showing improved electron conductivity and reduced beam-induced motion, leading to better particle distribution and resolution.

Integrative Modeling of a Sin3/HDAC Complex Sub-structure

The paper determines the spatial arrangement of Sin3 subunits around SIN3A using cross-linking and mass spectrometry, revealing their relative positions and interactions.