G. Tang

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

The DEAD-box helicase RCF1 plays roles in miRNA biogenesis and RNA splicing in Arabidopsis

This study identifies RCF1 as a key player in miRNA biogenesis and RNA splicing in Arabidopsis by showing its role in pri-miRNA processing and splicing defects in a mutant.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases

The paper evaluates distress parameters in animal models of gastrointestinal diseases and introduces RELSA, a composite score that robustly assesses severity across models.

An updated nomenclature for plant ribosomal protein genes

The paper proposes updated nomenclature for plant ribosomal protein genes to improve adoption in plant biology, extending previous systems to include organellar ribosomes and additional species.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

CTCF association with episomal HPV16 genomes regulates viral oncogene transcription and splicing

This study shows CTCF binds to HPV16 episomes, regulating oncogene transcription and splicing during viral lifecycle, with CTCF playing a greater role than SMC1A in viral gene expression and genome maintenance.

Adsorption mechanism of bacteria onto a Na-montmorillonite surface with organic and inorganic calcium

This study compares the adsorption of bacteria onto Na-montmorillonite using organic and inorganic calcium sources, finding organic calcium forms denser aggregates and is more environmentally friendly.

Biochar effect - mediated ammonium transporter genes and GDH may be the core of improvement nitrogen assimilation in cotton seedling

The paper investigates how biochar affects nitrogen assimilation in cotton seedlings by analyzing gene expression and enzyme activity under different urea and biochar conditions.

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson's disease mouse brain

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

Transcriptional Differences of Peanut (Arachis hypogaea L.) Seeds in the Fresh-harvest, After-ripened and Just-germinated States: insights into regulatory networks of seed dormancy-release and germination

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.