C. Mogler

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

NFAT5-dependent transcriptional stress control of endothelial cells prevents maladaptive remodeling of pulmonary arterioles in the hypoxic lung

This study shows that NFAT5 in endothelial cells limits hypoxia-induced maladaptive remodeling of pulmonary arterioles by restricting HIF1-mediated Pdgfb expression.

AhR-mediated activation of innate lymphocytes restrains tissue-resident memory-like CD8+ T cell responses during contact hypersensitivity

This study shows that AhR in NKp46+ ILCs limits CHS inflammation by modulating CD8+ TRM cells, with AhR deficiency leading to increased inflammation and TRM-like cells.

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis

This study shows that gut microbiota supports liver regeneration by promoting hepatic phospholipid synthesis, with antibiotic-induced dysbiosis impairing this process.

Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury

This study shows liver sinusoidal endothelial cells regulate NK cell recruitment and activation in acute liver inflammation by producing chemokines and responding to inflammatory signals.

Semaphorin 3C exacerbates liver fibrosis

This study identifies SEMA3C as a key driver of liver fibrosis by enhancing TGF-β signaling in hepatic stellate cells.

Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages

This study shows that different oils cause varying levels of peritoneal inflammation and macrophage depletion, with peanut oil causing severe chronic inflammation and olive oil promoting inflammation resolution.

YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis

This study shows YAP promotes liver tumor progression by altering the vascular niche, creating heterotypic communication between endothelial cell subtypes via HGF/c-MET signaling.