Author

D. Dilworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. H. Arrowsmith· 4 shared D. Barsyte-Lovejoy· 4 shared F. Li· 3 shared M. Vedadi· 3 shared P. J. Brown· 3 shared A. Allali-Hassani· 2 shared E. Gibson· 2 shared J. Min· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersCancer Biology

C. H. Arrowsmith

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Author profile →

4 papers

Recent·Most cited

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. M. Szewczyk, G. M. Luciani, V. Vu, A. Murison, D. Dilworth, M. Lupien, C. H. Arrowsmith, M. D. Minden, D. Barsyte-Lovejoy

This study shows PRMT5 regulates ATF4 splicing and oxidative stress response in AML, with EVI1-high cells depending on PRMT5 for redox balance.

bioRxiv · Feb 2, 2022Cancer Biology

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas, A. Allali-Hassani, M. Zhou, N. Mehta, M. R. Marunde, S. Ackloo, E. Marcon, F. Li, I. Chau, A. Bolotokova, S. Qin, M. Lei, Y. Liu, , M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

bioRxiv · Mar 5, 2021 · PreprintCell Biology

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

R. Ferreira de Freitas, Y. Liu, M. Szewczyk, N. Mehta, F. Li, D. McLeod, C. Zepeda-Velazquez, D. Dilworth, R. P. Hanley, E. Gibson, P. J. Brown, R. Al-Awar, L. Ingerman James, C. H. Arrowsmith, D. Barsyte-Lovejoy, , A. Allali-Hassani

This study identifies small-molecule antagonists of the NSD2 PWWP domain that block its interaction with H3K36me2, providing a tool for further investigation of NSD2's role in disease.

bioRxiv · Nov 25, 2020Pharmacology & Toxicology

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

M. M. Szewczyk, Y. Ishikawa, S. Organ, N. Sakai, F. Li, S. Ackloo, M. S. Eram, D. Dilworth, H. Fukushi, R. Harding, C. C. dela Sena, T. Sugo, K. Hayashi, D. Macleod, C. Zepeda, , D. Barsyte-Lovejoy

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

bioRxiv · Mar 15, 2019Biochemistry