Author

K. Devkota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Ecology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Research Focus:ecology & biodiversity· 2 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:diffusion model· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

F. Li· 4 shared M. Vedadi· 4 shared A. Bolotokova· 3 shared A. Khalili Yazdi· 3 shared P. Ghiabi· 3 shared S. Perveen· 3 shared T. Hajian· 3 shared I. Chau· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

F. Li

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Author profile →

6 papers

Recent·Most cited

Decline of honeybees and its consequences for beekeepers and crop pollination in western Nepal

S. Kortsch, T. P. Timberlake, A. Cirtwill, S. Sapkota, K. Devkota, T. Roslin, J. Memmott, N. Saville

This study reports a significant decline in honeybee populations and honey yields in western Nepal, linking the decline to climate change and reduced flower abundance, with implications for crop pollination and beekeeper livelihoods.

Insects · Apr 16, 2024Peer-reviewedEcology

The distribution of Apis laboriosa revisited: range extensions and biogeographic affinities

G. W. Otis, M.-J. Huang, N. Kitnya, U. A. A. Sheikh, A. u. A. Faiz, C. H. Phung, N. Warrit, Y.-Q. Peng, X. Zhou, H. M. Oo, N. Acharya, K. Devkota

This paper revises the distribution of Apis laboriosa, extending its range and discussing biogeographic affinities and new localities.

bioRxiv · Apr 4, 2024 · PreprintEcology

Structure-based discovery of inhibitors of the SARS-CoV-2 Nsp14 N7-methyltransferase

I. Singh, F. Li, E. Fink, I. Chau, A. Li, A. Rodriguez-Hernandez, I. Glenn, F. J. Zapatero-Belinchon, M. Rodriguez, K. Devkota, Z. Deng, K. White, X. Wan, N. A. Tolmachova, Y. S. Moroz, , B. K. Shoichet

The paper identifies multiple inhibitors of SARS-CoV-2 Nsp14 N7-methyltransferase using docking strategies, with some showing sub-10 M potency and selectivity.

bioRxiv · Jan 12, 2023 · PreprintBiophysics

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

K. Devkota, M. Schapira, S. Perveen, A. Khalili Yazdi, F. Li, I. Chau, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, K. J. Satchell, K. Wang, D. Li, J. Liu, D. Smil, , M. Vedadi

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

bioRxiv · Feb 19, 2021Biochemistry

A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

A. Khalili Yazdi, F. Li, K. Devkota, S. Perveen, P. Ghiabi, T. Hajian, A. Bolotokova, M. Vedadi

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

bioRxiv · Feb 3, 2021Biochemistry

A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

S. Perveen, A. Khalili Yazdi, K. Devkota, F. Li, P. Ghiabi, T. Hajian, P. Loppnau, A. Bolotokova, M. Vedadi

The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.

bioRxiv · Oct 14, 2020Biochemistry