A. Bove

Cell-scale biophysical determinants of cell competition in epithelia

The paper constructs a multi-scale agent-based model to study cell competition in epithelia, finding that mechanical competition depends on homeostatic density differences while biochemical competition depends on tissue organisation.

Polarization of Myosin II refines tissue material properties to buffer mechanical stress.

The paper identifies a mechanosensitive pathway that uses Myosin II polarization to stiffen tissues and buffer mechanical stress, preventing damage and preserving tissue shape.