Mechanosensitive nuclear asymmetries define a bipolar spindle scaffold to ensure mitotic fidelity
V. Nunes, M. Dantas, D. Castro, E. Vitiello, I. Wang, N. Carpi, M. Balland, M. Piel, P. Aguiar, H. Maiato, J. G. Ferreira
The paper shows that nuclear asymmetry during prophase, driven by mechanical cues, enables proper centrosome positioning and bipolar spindle formation for accurate mitosis.
bioRxiv · Nov 18, 2019 · PreprintCell Biology