A. Bueno-Orovio

This study shows lysosomal calcium handling promotes RyR spontaneous release by increasing SR-junction calcium gradient, and blocking lysosomal function reduces arrhythmias.

The paper combines human iPSC-CMs and in-silico models to identify genotype-specific pathomechanisms and therapeutic targets in hypertrophic cardiomyopathy.

This study identifies reduced potassium currents as the main mechanism of action potential prolongation in HCM under beta-adrenergic stimulation, leading to arrhythmogenic risks.

The paper updates the ToR-ORd model of human ventricular cardiomyocytes to include dynamic intracellular chloride, improving long-term simulation stability without significant complexity increase.

This paper introduces a computational method to generate physiologically realistic fibrosis patterns, demonstrating its application to cardiac fibrosis and showing micro-scale variability impacts on electrophysiology.