BioengineeringbioRxiv
Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics
R. P. Wallace, K. C. Refvik, J. T. Antane…·J. A. Hubbell
This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.
DOI 10.1016/j.xcrm.2023.101345