Cancer-Associated Hypercalcemia Signals Through the Hindbrain to cause Anorexia
D. Y. Grinman, F. M. Takyar, P. Dann, M. Shanabrough, S. Brown, A. Clemenceau, J. R. Hens, B. Stutz, L. A. Chodosh, W. Chang, G. I. Schulman, T. L. Horvath, J. J. Wysolmerski
This study shows that hypercalcemia from tumor-secreted PTHrP activates hindbrain circuits linked to anorexia, and blocking hypercalcemia prevents these effects.
bioRxiv · Mar 19, 2024 · PreprintCancer Biology