Author

A. D. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 2 Physiology· 2 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2

Frequent Co-Authors

C. E. Stewart· 3 shared D. J. Dupre· 2 shared D. N. Langelaan· 2 shared A. K. Larin· 1 shared A. P. Sharples· 1 shared B. Drust· 1 shared C. C. L. Tee· 1 shared C. Cranstone· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

C. E. Stewart

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Exercise on cytokine responses in males and females: Effect of leucine, HMB and BCAA.

A. D. Brown, M. Grammenou, C. C. L. Tee, M. C. Chong, C. E. Stewart

This study examines how leucine, HMB, and BCAA affect post-exercise cytokine responses in males and females, finding sex-specific differences in cytokine levels and responses to supplementation.

bioRxiv · Jul 11, 2023 · PreprintPhysiology

Macromolecular crowding is surprisingly unable to deform the structure of a model biomolecular condensate

J. C. Shillcock, D. Thomas, J. H. Ipsen, A. D. Brown

This study investigates how macromolecular crowding affects model biomolecular condensates, finding that crowding agents do not significantly alter their structure.

bioRxiv · Dec 12, 2022Biophysics

β-catenin interacts with the TAZ1 and TAZ2 domains of CBP/p300 to activate gene transcription

C. Cranstone, A. D. Brown, D. J. Dupre, D. N. Langelaan

This study identifies the interaction between β-catenin's C-terminal domain and CBP/p300's TAZ1/TAZ2 domains, revealing key residues critical for gene activation in Wnt/β-catenin signaling.

bioRxiv · Aug 30, 2022Biochemistry

Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor

A. D. Brown, K. L. Vergunst, M. Branch, C. M. Blair, D. J. Dupre, G. S. Baillie, D. N. Langelaan

This study identifies the structural basis of MITF's interaction with CBP/p300 TAZ domains, revealing an acidic motif essential for transcriptional activity and showing that E1A can inhibit this interaction.

bioRxiv · Aug 28, 2022Biochemistry

Angiogenesis is critical for the regenerative effects of exercise.

S. S. Wariyar, A. D. Brown, T. Tian, T. S. Pottorf, P. J. Ward

This study shows that fibrin glue repair combined with exercise enhances axon regeneration and functional recovery by promoting angiogenesis in nerve repairs.

bioRxiv · Nov 17, 2021 · PreprintCell Biology

Degradation of ribosome and chaperone proteins is attenuated during the Differentiation of Replicatively Aged C2C12 Myoblasts

A. D. Brown, C. E. Stewart, J. G. Burniston

This study shows that replicatively aged C2C12 myoblasts have reduced protein degradation, particularly of ribosomal and chaperone proteins, during differentiation, leading to impaired fusion and proteome quality.

bioRxiv · Oct 18, 2021 · PreprintCell Biology

Fluorogenic EXO-Probe Aptamers for Imaging and Tracking Exosomal RNAs

E. E. Bonacquisti, S. W. Ferguson, N. E. Jasiewicz, J. Wang, A. D. Brown, D. P. Keeley, M. S. Itano, J. Nguyen

This paper develops a fluorogenic EXO-Probe Aptamer system to visualize and track exosomal RNAs, enabling imaging, quantification, and colocalization with cellular markers.

bioRxiv · Aug 18, 2021 · PreprintBioengineering

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity

D. C. Turner, P. P. Gorski, M. F. Maasar, R. A. Seaborne, P. Baumert, A. D. Brown, M. O. Kitchen, R. M. Erskine, I. Dos-Remedios, S. Voisin, N. Eynon, R. I. Sultanov, O. V. Borisov, A. K. Larin, E. A. Semenova, , A. P. Sharples

This study identifies age-related hypermethylation in HOX genes in aged human skeletal muscle and stem cells, with physical activity inversely affecting methylation in some genes.

bioRxiv · Dec 27, 2019Physiology