Author

A. deCarvalho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Noushmehr· 2 shared T. Mikkelsen· 2 shared A. Cieslukowski· 1 shared A. D. Berezovsky· 1 shared A. H. Poral· 1 shared A. M. Robin· 1 shared A. Makherjee· 1 shared A. Shamisa· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

H. Noushmehr

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4 papers

Recent·Most cited

Impact of genomic background and developmental state on signaling pathways and response to therapy in Glioblastoma patient-derived cells

A. D. Berezovsky, O. Nuga, I. Datta, K. Bergman, T. Sabedot, K. Gurdziel, S. Irtenkauf, L. Hasselbach, Y. Meng, C. Mueller, E. Petricoin, S. Brown, N. Purandare, S. Aras, T. Mikkelsen, , A. deCarvalho

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

bioRxiv · Mar 14, 2024 · PreprintCancer Biology

Modelling Glioma Stem Cell-mediated Tumorigenesis Using Zebrafish PDX Systems

H. P. Mahendran, A. Cieslukowski, D. Lubanska, N. Philbin, K. F. Stringer, P. Habashy, M. Stover, A. deCarvalho, M. Soliman, A. Shamisa, L. Porter

This paper describes methods for generating zebrafish PDX systems to study GSC-mediated tumorigenesis and interactions with the tumor microenvironment.

bioRxiv · Feb 27, 2024 · PreprintCancer Biology

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

Y. Barekatain, V. C. Yan, J. J. Ackroyd, A. H. Poral, T. Tran, D. K. Georgiou, K. Arthur, A. deCarvalho, Y.-H. Lin, N. B. Satani, E. S. Ballato, R. Verhaak, J. de Groot, J. T. Huse, J. M. Asara, F. L. Muller

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

bioRxiv · Oct 18, 2019Cancer Biology

Detection of glioma and prognostic subtypes by non-invasive circulating cell-free DNA methylation markers

H. Noushmehr, T. S. Sabedot, T. M. Malta, K. Nelson, J. Snyder, M. Wells, A. deCarvalho, A. Makherjee, D. Chitale, M. Mosella, K. Asmaro, A. M. Robin, M. L. Rosenblum, T. Mikkelsen, J. Rock, , A. V. Castro

This study identifies non-invasive circulating DNA methylation markers that can detect glioma and predict its prognosis from serum samples.

bioRxiv · Apr 8, 2019 · PreprintCancer Biology