Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor
J. Personnaz, E. Piccolo, A. Dortignac, J. S. Iacovoni, J. Mariette, A. Polizzi, A. Batut, S. Deleruyelle, R. Paccoud, E. Moreau, F. Martins, T. Clouaire, F. Benhamed, A. Montagner, W. A. Wahli, , J.-P. Pradere
This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.
bioRxiv · Feb 17, 2021 · PreprintPathology