C.-H. Lee

PET imaging of fibroblast activation protein alpha (FAP) detects incipient cardiotoxicity due to anthracycline chemotherapy

This study shows that PET imaging with [68Ga]Ga-FAPI-04 detects early cardiotoxicity from anthracycline chemotherapy before echocardiography, by targeting fibroblast activation protein alpha (FAP).

Epidermal Growth Factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

The paper shows EGF enhances TNBC cells' response to CAP-activated medium by activating specific EGFR phospho-tyrosines and increasing ROS levels.

Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

This paper develops a finite element model of the chinchilla inner ear to study how CI electrode insertion angle affects residual hearing, finding minimal hearing loss with optimal angles.

Molecular mechanism of substrate recognition by folate transporter SLC19A1

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

EZH2/ hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

This study identifies the EZH2/SULF1/cMET axis as a driver of chondrosarcoma progression and shows that targeting this pathway can slow tumor growth and improve survival in mouse models.

Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma

This study characterizes the tumor microenvironment of renal medullary carcinoma using genomic, metabolic, and single-cell RNA-sequencing data, identifying key molecular features and potential therapeutic targets.

A protocol for the reduction of applied torque on parent vessel duringelastase-induced aneurysm formation using rabbit animal models

This study modifies an elastase-induced aneurysm model in rabbits to reduce parent vessel torque and improve aneurysm stability for endovascular device testing.

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

This study compares the genomic and metabolic features of SDH- and FH-deficient renal cell carcinomas, identifying distinct genetic and metabolic abnormalities.

Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.

Bmal1 integrates mitochondrial metabolism and macrophage activation

This study shows Bmal1 integrates mitochondrial metabolism and macrophage activation, with implications for immunotherapy and inflammatory diseases.

Asparagine deprivation causes a reversible inhibition of Human Cytomegalovirus acute virus replication

This study identifies asparagine as a critical factor for HCMV replication through a large-scale siRNA screen, showing that its depletion inhibits virus replication but allows recovery with exogenous asparagine.

Structure-function analyses of a keratin heterotypic complex identify specific keratin regions involved in intermediate filament assembly

The paper determines the crystal structure of a keratin 5 and 14 2B domain complex and identifies key interactions critical for intermediate filament assembly.

Long-term impact of intensive postgraduate laboratory training at the Cold Spring Harbor Neurobiology of Drosophila summer course

This paper evaluates the long-term impact of a postgraduate Drosophila neuroscience summer course on participants' careers and scientific training.

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

Distinct stimulatory mechanisms regulate the catalytic activity of Polycomb Repressive Complex 2 (PRC2)

The paper shows that EZH1 and EZH2, two catalytic subunits of PRC2, are differentially activated to regulate H3K27 methylation, with AEBP2 adding additional stimulation.

Identification of Tumor-Reactive B Cells and Systemic IgG in Breast Cancer Based on Clonal Frequency in the Sentinel Lymph Node

The paper identifies tumor-reactive B cells in sentinel lymph nodes and links them to systemic IgG antibodies in breast cancer patients using high-throughput sequencing and immunoproteomics.

Allosteric activation dictates PRC2 activity independent of its recruitment to chromatin

This study shows that PRC2 activity is controlled by allosteric activation, independent of its chromatin recruitment, and identifies vulnerabilities in PRC2-addicted cancers.