Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation
A. Saragovi, X. Zheng, I. Abramovich, L. Cohen-Daniel, L. Zhuoning, H. Raifer, I. Omar, A. Swisa, M. Kuchersky, A. Drori, F. Marini, O. Toker, R. Somech, C. Schmidl, R. C. Hendrickson, , M. Berger
This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.
bioRxiv · Aug 16, 2022 · PreprintImmunology