A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913
J. Kazmierski, C. Elsner, K. Doehner, S. Xu, A. Ducroux, F. Pott, J. Jansen, C. W. Thorball, O. Zeymer, X. Zhou, R. Fedorov, J. Fellay, M. W. Loeffler, A. N. R. Weber, B. Sodeik, C. Goffinet
This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.
bioRxiv · Aug 24, 2021 · PreprintImmunology