J. Jansen

The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress

Spatial niche separation of an invasive and a native mesopredator

The paper examines spatial niche separation between invasive feral cats and native western quolls in South Australia, finding they occupy distinct habitats with cats preferring grasslands and quolls avoiding areas with high cat density.

The effects of alternative rabbit control methods on feral cat activity in an open, semi-arid landscape

This study tests how reducing European rabbit populations affects feral cat activity using camera surveys in South Australia, finding that only warren destruction significantly altered cat detections.

The Antarctic Seafloor Annotated Imagery Database

The paper introduces AS-AID, a database of annotated Antarctic seafloor images for biodiversity and habitat analysis.

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

Lipid Droplets Fuel Small Extracellular Vesicle Biogenesis

This study shows that lipid droplets are linked to small extracellular vesicle biogenesis and that manipulating lipid droplets can affect sEV secretion and cargo.

Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism

This study shows JQ-1 inhibits SARS-CoV-2 replication via NRF-2 activation but is counteracted by viral antagonism, leading to transient antiviral effects.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

A base-line cellular antiviral state is maintained by cGAS and its most frequent naturally occurring variant rs610913

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

Lipid Droplets and Ferritin Heavy Chain: a Devilish Liaison in Cancer Radioresistance

The paper identifies a novel mechanism linking lipid droplets and ferritin heavy chain in cancer radioresistance, showing that FTH1 promotes radioresistance through LD accumulation.

A comprehensive landscape of 60S ribosome biogenesis factors

The paper maps RBF interactions during 60S ribosome maturation using proteomics and XL-MS, identifying new factors and elucidating their roles.

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

This paper develops small, porous tubular scaffolds using melt-electrowriting to enhance engineered kidney tubule functionality through microgeometry-directed cell behavior.

Type I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunity

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

Mapping Antarctic suspension feeder abundances and seafloor food-availability, and modelling their change after a major glacier calving

The paper maps suspension feeder abundances in East Antarctica and predicts their changes after the Mertz Glacier calving, showing increased abundances near the calving site due to higher food supply.