K. Takeda

OrgaMeas: A pipeline that integrates all the processes of organelle image analysis

OrgaMeas provides a high-throughput image analysis pipeline for accurate organelle morphology and dynamics measurement using deep learning tools.

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Viral Syncytia Evolve to Resist Interferon

This study shows that SARS-CoV-2 syncytia reduce interferon and antibody effectiveness, explaining the evolution of fusogenic viral variants.

Analysis of chronic host-aspergilloma interactions using a novel mouse model

This paper develops a novel mouse model of aspergilloma to study host-fungal interactions, revealing Th1/Th17 responses and angiogenesis induced by dead fungal hyphae.

Genome-wide neighbor effects predict genotype pairs that reduce herbivory in mixed planting

The paper identifies genotype pairs in Arabidopsis thaliana that reduce herbivory through associational resistance when planted in mixtures.

Subchronic Toxicity Assessment of Perfluoroalkyl Substances by Mixed Exposure of Nine Substances at Daily Intake Relevant Concentration

This study assesses the subchronic toxicity of a PFAS mixture in mice, finding liver morphological changes and alterations in metabolism and cancer-related gene expression.

Structural dynamics of E6AP E3 ligase HECT domain and involvement of flexible hinge loop in ubiquitin chain synthesis mechanism

This study uses high-speed atomic force microscopy to demonstrate the structural dynamics of the E6AP HECT domain and shows how hinge loop flexibility affects Ub chain formation.

Collaborative hunting in artificial agents with deep reinforcement learning

This study shows that collaborative hunting in artificial agents can emerge through simple decision rules using deep reinforcement learning, without requiring complex cognitive processes.

High-content phenotypic screen to identify small molecule enhancers of parkin-dependent ubiquitination and mitophagy

The paper identifies small molecule enhancers of parkin-dependent ubiquitination and mitophagy through a high-content phenotypic screen in patient-derived fibroblasts.

Skin resident memory cells generated by the L. major centrin gene deleted parasites mediate protective immune response analogous to leishmanization

This study shows that a genetically modified Leishmania vaccine generates skin-resident memory T cells that provide protection similar to leishmanization.

Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2

The paper establishes a SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells expressing ACE2 and TMPRSS2, showing good correlation with other assays.

Slippery flowers as a mechanism of defence against nectar-thieving ants

The paper investigates how slippery floral surfaces deter nectar-thieving ants in two plant species, finding that epicuticular wax crystals reduce ant entry and affect pollinator behavior.

Disease stage-specific pathogenicity of CD138 (syndecan 1)-expressing T cells in systemic lupus erythematosus

This study identifies CD138-expressing T cells in SLE-prone mice, showing their pathogenic role in disease progression and potential as a therapeutic target.

PP2AB55δ Responsible for the High Initial Rates of Alcoholic Fermentation in Sake Yeast Strains of Saccharomyces cerevisiae

This study identifies PP2AB55δ as a mediator of high fermentation rates in sake yeast strains through the TORC1-Greatwall-PP2AB55δ pathway.

Neuraminidase Inhibition Contributes to Influenza A Virus Neutralization by Anti-Hemagglutinin Stem Antibodies

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed ankylosing arthritis

This study evaluates the effectiveness of an anti-IL-6 receptor antibody in reducing synovitis and bone destruction in McH-lpr/lpr-RA1 mice with ankylosing arthritis, showing partial success in inflammation but not in preventing ankylosis progression.

Influenza A Virus Negative Strand RNA is Translated for CD8+ T Cell Immunosurveillance

This study shows that influenza A virus negative strand RNA can be translated into proteins recognized by CD8+ T cells, challenging the notion that viral negative strands are non-coding.