R. K. June

This study compares metabolomic profiles of healthy and osteoarthritic human cartilage to identify disease-associated metabolic endotypes and pathways.

This study tests diffusion of 3kDa tracers from bone-to-cartilage in bovine osteochondral cores under different loading conditions and finds significant fluid transport with cyclic compression affecting tracer concentration.

This study identifies metabolic pathway alterations and candidate biomarkers in early-stage ADPKD using metabolomic profiling of urine samples.

This study identifies distinct metabolomic profiles in synovial fluid associated with knee injury types and patient sex, suggesting metabolic differences linked to post-traumatic osteoarthritis development.

This study compares metabolomic biomarkers in synovial fluid and serum of injured mice to understand early osteoarthritis responses and identify potential biomarkers.

This study examines bone and synovial fluid changes 7 days after ACL injury in mice, finding altered bone microarchitecture and distinct metabolic shifts in injured limbs.

The study compares metabolomes of cortical bone, whole bone, and bone marrow in C57BL/6J mice, revealing sex differences and associations with bone strength.

The paper compares shear- and compression-induced mechanotransduction in SW1353 chondrocytes using metabolomics to identify altered pathways.

The paper develops and validates a finite element model of fluid transport in osteochondral tissue, showing pressure gradients at the cartilage-bone interface during loading.

This study uses alginate microgels to culture single chondrocytes and examines their metabolomic responses to mechanical loading, showing distinct profiles compared to controls.

This study develops a 3-D constitutive model for high-stiffness agarose gels to predict intra-gel stresses in cell-seeded constructs, enabling better mechanobiology analysis.

This study compares the early joint injury responses in germ-free and conventional mice, finding that germ-free mice show less bone loss and distinct metabolic profiles linked to immune regulation.

This study evaluates the TAT peptide transduction domain as a drug delivery method for intra-articular therapies, showing its ability to deliver siRNA and induce genetic recombination in vivo.