Author

A. F. Munro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Assay:imaging· 1 Assay:metabolomics· 1

Frequent Co-Authors

N. O. Carragher· 3 shared A. Makda· 2 shared J. R. O'Neill· 2 shared R. E. Hughes· 2 shared R. J. R. Elliott· 2 shared T. Hupp· 2 shared K. Fujihara· 1 shared N. J. Clemons· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

N. O. Carragher

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivJul 19, 2023

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death.

R. E. Graham, R. J. R. Elliott, A. F. Munro, N. O. Carragher

This paper shows that N-acetylcysteine reduces copper uptake rather than quenching reactive oxygen species, challenging the current understanding of copper-induced cell death mechanisms.

DOI 10.1371/journal.pone.0294297

experimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 5, 2021

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

R. E. Hughes, R. J. Elliott, X. Li…·N. O. Carragher

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

DOI 10.1101/2021.10.05.463189

humanmetabolomics

𝕏 PostBluesky

Cancer BiologybioRxivJan 20, 2020

High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

R. E. Hughes, R. J. R. Elliott, A. F. Munro…·N. O. Carragher

This study uses high-content phenotypic profiling to identify drug classes and novel compounds with selective activity against oesophageal adenocarcinoma cell lines.

DOI 10.1177/2472555220917115

humanimaging

𝕏 PostBluesky