Author

T. Hupp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. F. Munro· 2 shared A. Makda· 2 shared J. R. O'Neill· 2 shared N. O. Carragher· 2 shared R. E. Hughes· 2 shared A. Igbaria· 1 shared A. Mohtar· 1 shared B. Vojtesek· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

A. F. Munro

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SRSF1 as a novel interacting partner for IFITM1/3 unravels the emergent role of IFITM1/3 mediating protein expression

S. Kote, M. Gomez-Herranz, J. Faktor, M. Yebenes Mayordomo, M. Pilch, L. Hernychova, K. L. Ball, B. Vojtesek, T. Hupp

This study identifies SRSF1 as an interacting partner of IFITM1/3, revealing their role in regulating protein synthesis by interacting with HLA-B mRNA and affecting ribosomal function.

bioRxiv · Feb 2, 2022 · PreprintCancer Biology

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

R. E. Hughes, R. J. Elliott, X. Li, A. F. Munro, A. Makda, R. N. Carter, N. M. Morton, K. Fujihara, N. J. Clemons, R. Fitzgerald, J. R. O'Neill, T. Hupp, N. O. Carragher

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

bioRxiv · Oct 5, 2021 · PreprintCancer Biology

Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors

D. Sicari, R. Pineau, P.-J. Le Reste, L. Negroni, S. Chat, A. Mohtar, D. Thomas, R. Gillet, T. Hupp, E. Chevet, A. Igbaria

The paper identifies a mechanism where ER proteins are refluxed to the cytosol, inactivating tumor suppressors like p53 in glioblastoma cells.

bioRxiv · Apr 13, 2020Cell Biology

High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

R. E. Hughes, R. J. R. Elliott, A. F. Munro, A. Makda, J. R. O'Neill, T. Hupp, N. O. Carragher

This study uses high-content phenotypic profiling to identify drug classes and novel compounds with selective activity against oesophageal adenocarcinoma cell lines.

bioRxiv · Jan 20, 2020Cancer Biology