N. O. Carragher

This paper shows that N-acetylcysteine reduces copper uptake rather than quenching reactive oxygen species, challenging the current understanding of copper-induced cell death mechanisms.

This study identifies a novel ILK-STAT3 pathway that regulates phenotypic plasticity and mesenchymal state in mouse glioblastoma stem cells.

This study identifies a unified mechanism of copper ionophore-induced cell death in oesophageal adenocarcinoma using high-content profiling and omic analyses.

This paper integrates multicenter reverse-phase protein array data from breast cancer cell responses to two drugs, quantifying 86,832 spots across three platforms to create a public resource for comparing RPPA workflows.

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

The paper presents strategies for designing optimized chemogenomic libraries for precision oncology, focusing on cancer-related targets and biological pathways.

This study uses high-content phenotypic profiling to identify drug classes and novel compounds with selective activity against oesophageal adenocarcinoma cell lines.

The paper identifies compounds that reverse nuclear size changes in cancer cell lines and finds they inhibit cell migration and invasion.

The paper assesses variability between RPPA platforms and identifies consistent protein expression and phosphorylation signatures across different platforms and workflows.

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

The paper identifies a synergistic combination of FAK and HDAC inhibitors using a chemical-genetic high-content screen, showing efficacy in cancer cell lines and in vivo.