Cell BiologybioRxiv
Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic
H. Stewart, R. Palmulli, K. H. Johansen…·J. R. Edgar
This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.
DOI 10.15252/embr.202357224