Author

N. McGovern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Appios· 2 shared A. Moffett· 2 shared A. Sharkey· 2 shared F. Ginhoux· 2 shared R. S. Hamilton· 2 shared X. X. Zhao· 2 shared A. A. Peden· 1 shared A. Firth· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

A. Appios

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

J. R. Thomas, A. Appios, E. F. Calderbank, X. X. Zhao, R. S. Hamilton, A. Moffett, A. Sharkey, E. Laurenti, N. McGovern

The paper identifies placental erythro-myeloid progenitors (PEMPs) that generate Hofbauer cells, showing human primitive haematopoiesis occurs in the placenta, not just the yolk sac.

bioRxiv · Feb 26, 2022 · PreprintImmunology

Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic

H. Stewart, R. Palmulli, K. H. Johansen, N. McGovern, O. M. Shehata, G. W. Carnell, H. K. Jackson, J. S. Lee, J. C. Brown, T. C. Burgoyne, J. L. Heeney, K. Okkenhaug, A. Firth, A. A. Peden, J. R. Edgar

This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.

bioRxiv · Jan 6, 2021Cell Biology

Phenotypic and functional characterisation of first trimester human placental macrophages, Hofbauer cells.

J. Thomas, A. Appios, X. X. Zhao, R. A. Dutkiewicz, M. J. Donde, C. Lee, P. M. Naidu, C. Lee, J. Cerveira, B. Liu, F. Ginhoux, G. Burton, R. S. Hamilton, A. Moffett, A. Sharkey, N. McGovern

The paper characterizes first trimester human placental macrophages, identifying Hofbauer cells as HLA-DR-FOLR2+ macrophages with microbicidal properties and secreted factors influencing placental angiogenesis.

bioRxiv · Sep 3, 2020Immunology

Trimester-specific Zika virus infection affects placental responses in women

F. M. Lum, V. Narang, S. Hue, C. Jie, N. McGovern, R. Rajarethinam, J. Tan, S. N. Amrun, Y. H. Chan, C. Y. P. Lee, T. K. Chua, W. X. Yee, N. K. W. Yeo, T. C. Tan, L. Xuan, , L. Ng

This study examines how ZIKV infection during different pregnancy trimesters affects placental immune and transcriptomic responses, identifying unique molecular changes associated with early infection.

bioRxiv · Aug 6, 2019 · PreprintImmunology