Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms
C. Gruen, H. H. Yang, A. Sassano, E. Wu, V. Gopalan, K. L. Marie, A. Castro, F. R. Mehrabadi, C. H. Wu, I. Church, G. A. Needle, C. Smith, S. Chin, J. Ebersole, C. Marcelus, , E. Perez-Guijarro
The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.
bioRxiv · Apr 3, 2023 · PreprintCancer Biology