Author

S. Chin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2 Plant Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Approach:experimental assay· 8 Assay:bulk RNA-seq· 5 Organism:mouse· 5 Research Focus:differential expression· 4 Organism:human· 3 Approach:statistical model· 3 Organism:Arabidopsis· 2

Frequent Co-Authors

C.-P. Day· 3 shared E. Perez-Guijarro· 3 shared G. Merlino· 3 shared K. L. Marie· 3 shared A. Fon· 2 shared A. Sassano· 2 shared C. Bear· 2 shared C. Smith· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

C.-P. Day

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Hypoxia-sensing by the Histone Demethylase UTX (KDM6A) Controls Colitogenic CD4+ T cell Fate and Mucosal Inflammation

M. I. Cheng, L. Hong, B. K. Chen, S. Chin, C. R. Luthers, C. Bustillos, S. Sheikh, M. Su

This study shows that UTX, an oxygen-sensitive histone demethylase, modulates colitis severity by affecting CD4+ T cell function and epigenetic regulation under hypoxia.

bioRxiv · Jul 27, 2023 · PreprintImmunology

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

C. Gruen, H. H. Yang, A. Sassano, E. Wu, V. Gopalan, K. L. Marie, A. Castro, F. R. Mehrabadi, C. H. Wu, I. Church, G. A. Needle, C. Smith, S. Chin, J. Ebersole, C. Marcelus, , E. Perez-Guijarro

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

Glycome profiling and immunohistochemistry uncover spaceflight-induced changes in non-cellulosic cell wall components in Arabidopsis thaliana seedling roots

J. Nakashima, S. Pattathil, U. Avci, S. Chin, J. A. Sparks, M. G. Hahn, S. Gilroy, E. B. Blancaflor

bioRxiv · Mar 14, 2023 · PreprintPlant Biology

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

V. Gopalan, C. W. Wong, R. Leshem, L. Owen, T. Vallius, Y. Shi, Y. Jiang, E. Perez-Guijarro, E. Wu, S. Chin, J. Ebersole, C. Smith, A. Sassano, M. Alves Constantino, M. J. Haley, , K. L. Marie

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

M. I. Cheng, L. Riggan, J. H. Li, R. Y. Tafti, S. Chin, F. Ma, M. Pellegrini, H. Hrncir, A. P. Arnold, T. E. O'Sullivan, M. A. Su

This study identifies UTX as a key X-linked epigenetic regulator causing sex differences in NK cell function, with males showing reduced IFN-γ production despite higher numbers.

bioRxiv · Apr 21, 2022 · PreprintImmunology

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

M. Ogawa, J.-X. Jiang, S. Xia, D. Yang, A. Ding, O. Laselva, S. Chin, M. Hernandez, C. Cui, Y. Higuchi, H. Suemizu, C. Dorrell, M. Grompe, C. Bear, G. Keller, S. Ogawa

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

bioRxiv · Mar 23, 2021Cell Biology

Spatial and Temporal Localization of SPIRRIG and WAVE/SCAR Reveal Roles for These Proteins in Actin-Mediated Root Hair Development

S. Chin, T. Kwon, B. R. Khan, J. A. Sparks, E. L. Mallery, D. B. Szymanski, E. B. Blancaflor

This study identifies the spatial and temporal roles of SPIRRIG and WAVE/SCAR proteins in actin-mediated root hair development through localization analysis and functional assays.

bioRxiv · Nov 13, 2020 · PreprintPlant Biology

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapy

E. Perez-Guijarro, H. H. Yang, R. E. Araya, R. El Meskini, H. T. Michael, S. K. Vodnala, K. L. Marie, C. Graff-Cherry, S. Chin, A. J. Iacovelli, A. Kulaga, A. Fon, A. M. Michalowski, W. Hugo, R. S. Lo, , G. Merlino

The paper develops a preclinical platform using syngeneic mouse models to predict melanoma patient response to immunotherapy and identifies a melanocytic plasticity signature linked to treatment outcomes.

bioRxiv · Aug 6, 2019 · PreprintCancer Biology

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

S. Chin, M. Ramjeesingh, M. Hung, J. Ereno-Oreba, C. E. Ing, Z. W. Zeng, H. Cui, J.-P. Julien, R. Pomes, C. Bear

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.

bioRxiv · Dec 16, 2018 · PreprintBiophysics