Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4+ T cells
P. Bhattacharjee, M. Pakusch, M. Lacorcia, E. Tresoldi, A. F. Rubin, A. Foster, L. S. King, C. Chiu, T. Kay, J. A. Karas, F. J. Cameron, S. I. Mannering
This study identifies 13 new proinsulin-derived HIPs recognized by human islet-infiltrating CD4+ T cells in T1D, highlighting proinsulin C-peptide's central role in HIP formation.
bioRxiv · May 9, 2024Immunology