RUNX/CBFβ transcription factor complexes promote the phenotypic plasticity of metastatic breast cancer cells
R. Ran, H. Harrison, N. S. Ariffin, R. Ayub, H. Pegg, W. Deng, A. Mastro, P. Ottewell, A. Fowles, S. Mason, K. Blythe, I. Holen, P. Shore
This study shows that RUNX/CBFβ complexes drive phenotypic plasticity in metastatic breast cancer cells by promoting EMT and enabling MET reversal.
bioRxiv · Feb 27, 2019 · PreprintCancer Biology